User:Wayne Decatur/Gal 4

From Proteopedia

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Gal4p is a transcriptional activator in Saccharomyces cerevisiae that regulates the expression of genes to coordinate the response to the carbon source galactose. Structures

spinqualitylabelsall models The N-terminal amino acids of Gal4p bound to DNA. Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

DNA Recognition by Gal4p

Gal4p is a transcriptional activator in Saccharomyces cerevisiae that regulates the expression of genes to coordinate the response to the carbon source galactose. The structure of The protein binds as a dimer to a symmetrical 17-base-pair sequence. Specifically, the consensus Gal4-binding site is a 17-mer of sequence 5′-CGG-N11-CCG-3′.

Reference

• Marmorstein R, Carey M, Ptashne M, Harrison SC. DNA recognition by GAL4: structure of a protein-DNA complex. Nature. 1992 Apr 2;356(6368):408-14. PMID:1557122 doi:http://dx.doi.org/10.1038/356408a0