Pyruvate dehydrogenase kinase

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Pyruvate dehydrogenase kinase (PDK) is part of the pyruvate dehydrogenase complex. This complex is located in the mitochondria and converts pyruvate to acetyl-CoA as part of the citric acid cycle. PDK phosphphorylates serine residues on pyruvate dehydrogenase using ATP. There are 4 isozymes of PDK. The isozymes differ in length, activity and phosphorylation sites.

3D structures of pyruvate dehydrogenase kinase

Updated on 26-May-2015

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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