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Contents 1 TGFβ signalling pathway 1.1 Ligands 1.1.1 TGFβ isoforms 1.2 TGFβ receptors 1.2.1 TGFβ receptor ectodomain 1.2.2 TGFβ receptor endodomain 1.3 TGFβ signalling 1.3.1 Latent TGFβ structure and activation 1.3.2 TGFβ-1:TβRII:TβRI ternary complex

TGFβ signalling pathway

Ligands

TGFβ isoforms

TGFβ receptors

TGFβ receptor ectodomain

TGFβ receptor endodomain

TGFβ signalling

Latent TGFβ structure and activation

==== pro-TGFβ-1 processing

TGFβ-1:TβRII:TβRI ternary complex