Sphingomyelinase

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Template:STRUCTURE 1zwx

Sphingomyelinase (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide. The SMase is classified into 5 types according to their pH dependence and cation dependence.

3D structures of sphingomyelinase

Updated on 16-June-2015

3rlh, 3rlg – SMase D (mutant) – Loxosceles intermedia
1xx1, 2f9r – SMase I – Loxosceles laeta
1zwx – SMase C – Listeria ivanovii
2ddr, 2dds, 2ddt – BcSMase + cation – Bacillus cereus
2uyr – BcSMase (mutant)
3wcx – SMase C – Streptomyces griseocarneus

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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