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Contents 1 TGFβ signalling pathway 1.1 Ligands 1.1.1 TGFβ isoforms 1.2 TGFβ receptors 1.2.1 TGFβ receptor ectodomain 1.2.2 TGFβ receptor endodomain 1.3 TGFβ signalling 1.3.1 Latent TGFβ structure and activation 1.3.1.1 pro-TGFβ-1 processing 1.3.2 TGFβ-1:TβRII:TβRI ternary complex

TGFβ signalling pathway

load='2QCQ' size='400' side='right' TGFβ belongs to a group of extracellular signals involved in the regulation of several cellular processes as cell proliferation, differentiation, Apoptosis, development, cellular adhesion, immune surveillance and Tissue homeostasis. In addition they are involved in pathological conditions as autoimmune diseases, Inflammatory diseases, cancer and Cardiovascular diseases

Ligands

TGFβ represents a paradigm of these group of ligands

TGFβ isoforms

TGFβ receptors

TGFβ receptor ectodomain

TGFβ receptor endodomain

TGFβ signalling

Latent TGFβ structure and activation

pro-TGFβ-1 processing

TGFβ-1:TβRII:TβRI ternary complex