Urokinase

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Urokinase (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage into catalytic domain (residues 179-431) and short chain (residues 156-178).

3D Structures of urokinase

Updated on 25-June-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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