Netrin

From Proteopedia

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spinqualitylabelsall models Mouse netrin-1 (PDB code 4ove) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Netrins (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types. Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Disease Relevance Structural highlights

3D Structures of netrin

Updated on 01-July-2015 {{#tree:id=OrganizedByTopic|openlevels=0|

• Netrin-1

• • 4ove – mNet1 – mouse
    
  • 4plm – cNet1 LN-LE3 domains – chicken
    
  • 4pln – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains
    
  • 4plo – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains
    
  • 4urt – hNet1 LN-LE3 domains + hNet receptor DCC fourth fibronectin type V-VI domains - human
    

• Netrin-G2

• • 3tbd – hNetG2 VI + LE1 domains
    
  • 3zyg – hNetG2 LAM + EGF1 domains
    
  • 3zyi – hNetG2 LAM + EGF1 domains + leucine-rich repeat-containing protein
    

References