Symplekin

From Proteopedia

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spinqualitylabelsall models Human symplekin N terminal (grey) complex with RNA polymerase II subunit A C terminal phosphatase (green) and phosphate ion (PDB code 3o2s) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Symplekin (SMPK) is a scaffold protein recruiting regulatory factors to the multimolecular complex involved in histone mRNA 3’-end processing. SMPK is involved in pre-mRNA polyadenylation. It enhances the activity of RNA polymerase II subunit A C terminal phosphatase (Ssu72). Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Disease Relevance Structural highlights

3D Structures of symplekin

Updated on 08-July-2015

3gs3 – DmSMPK N terminal – Drosophila melanogaster
3o2t, 3odr – hSMPK N terminal – human
3ods – hSMPK N terminal (mutant)
3o2s – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase
4h3h, 3o2q, 4h3k – hSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide
4imi, 4imj – DmSMPK N terminal + RNA polymerase II subunit A C terminal phosphatase + phosphorylated peptide

References