Structural highlights
Function
[H1A03_HAPHA] Is a depressant toxin. Blocks the SCN2A/SCN1B (Nav1.2/Beta1) sodium channel receptor (IC(50) is 68 +-6 uM) and the insect sodium channel para/tipE (IC(50) is 4.3 +-0.3 uM), without altering the activation or inactivation kinetics.[1]
References
- ↑ Li D, Xiao Y, Hu W, Xie J, Bosmans F, Tytgat J, Liang S. Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana. FEBS Lett. 2003 Dec 18;555(3):616-22. PMID:14675784
