Tumor necrosis factor receptor

Function

Tumor necrosis factor receptor (TNFR) or death receptor is a trimeric cytokine receptor which binds TNF. TNFR family contains several members and superfamily (TNFRSF) members. The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains.

• TNFRSF 6 is called Fas;
  
• TNFRSF 10B is called Dr5;
  
• TNFRSF 16 is called Nerve growth factor receptor;
  
• TNFRSF 21 is called Dr6;
  
• TNFRSF 11A is called RANK;
  
• TNFRSF 18 is called GITRL.

Disease

Relevance

Structural highlights