Core-binding factor (CBF) is a heterodimeric transcription factor which is composed of α chain which binds DNA and a regulatory β chain. CBF binds to various enhancers and promoters including murine leukemia virus and polyomavirus enhancer. CBF α contains a DNA-binding runt domain (residues 50-177).
Function
Disease
Mutations in CBF β are implicated in breast cancer. Rearrangements of CBF α and β genes are implicated in acute myeloid leukemia.
Relevance
Structural highlights