Pyranose oxidase or pyranose 2-oxidase (P2O) catalyzes the conversion of D-glucose and molecular oxygen to 2-dehydro-D-glucose and H2O2. It is abundant in lignin-degrading white rot fungi. P2O is a tetramer flavoprotein containing the prosthetic group FAD in each monomer. P2O oxidizes several aldopyranoses with the preferred electron donors being D-glucose, D-xylose and D-sorbose.
Function
Disease
Relevance
Converting common sugars and sugar derivatives with P2O provides a pool of sugar-derived intermediates for the synthesis of rare sugars, fine chemicals and drugs.
Structural highlights
