9gpb

From Proteopedia

Revision as of 17:16, 20 March 2008 by OCA (Talk | contribs)
Jump to: navigation, search
Image:9gpb.gif


PDB ID 9gpb

Drag the structure with the mouse to rotate
, resolution 2.9Å
Ligands: and
Activity: Phosphorylase, with EC number 2.4.1.1
Coordinates: save as pdb, mmCIF, xml



THE ALLOSTERIC TRANSITION OF GLYCOGEN PHOSPHORYLASE


Overview

The crystal structure of R-state glycogen phosphorylase b has been determined at 2.9 A resolution. A comparison of T-state and R-state structures of the enzyme explains its cooperative behaviour on ligand binding and the allosteric regulation of its activity. Communication between catalytic sites of the dimer is provided by a change in packing geometry of two helices linking each site with the subunit interface. Activation by AMP or by phosphorylation results in a quaternary conformational change that switches these two helices into the R-state conformation.

About this Structure

9GPB is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

The allosteric transition of glycogen phosphorylase., Barford D, Johnson LN, Nature. 1989 Aug 24;340(6235):609-16. PMID:2770867

Page seeded by OCA on Thu Mar 20 19:16:20 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9gpb"
Personal tools