2lr9

Structural highlights

Function

[CA1A_CONTU] Allosteric inhibitor of alpha-1B adrenergic receptors (ADRA1B). Binds to an allosteric modulatory site on transmembrane helix 6 and 7 at the base of extracellular loop 3 of ADRA1B (PubMed:23184947). Also weekly inhibits alpha-1A (ADRA1A) and alpha-1D (ADRA1D) adrenergic receptors in a competive manner (PubMed:15194691). Potently inhibits contractions of vas deferens, spleen and aorta in response to noradrenaline (PubMed:15680270).^{[1] [2] [3] [4] [5]}

References

1. ↑ Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ. Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter. Nat Neurosci. 2001 Sep;4(9):902-7. PMID:11528421 doi:http://dx.doi.org/10.1038/nn0901-902
2. ↑ Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF, Adams DJ, Lewis RJ. Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA. J Biol Chem. 2003 Sep 5;278(36):34451-7. Epub 2003 Jun 24. PMID:12824165 doi:http://dx.doi.org/10.1074/jbc.M305410200
3. ↑ Chen Z, Rogge G, Hague C, Alewood D, Colless B, Lewis RJ, Minneman KP. Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA. J Biol Chem. 2004 Aug 20;279(34):35326-33. Epub 2004 Jun 11. PMID:15194691 doi:http://dx.doi.org/10.1074/jbc.M403703200
4. ↑ Lima V, Mueller A, Kamikihara SY, Raymundi V, Alewood D, Lewis RJ, Chen Z, Minneman KP, Pupo AS. Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta. Eur J Pharmacol. 2005 Jan 31;508(1-3):183-92. Epub 2005 Jan 12. PMID:15680270 doi:http://dx.doi.org/10.1016/j.ejphar.2004.12.011
5. ↑ Ragnarsson L, Wang CI, Andersson A, Fajarningsih D, Monks T, Brust A, Rosengren KJ, Lewis RJ. Conopeptide rho-TIA defines a new allosteric site on the extracellular surface of the alpha1B-adrenoceptor. J Biol Chem. 2013 Jan 18;288(3):1814-27. doi: 10.1074/jbc.M112.430785. Epub 2012 , Nov 26. PMID:23184947 doi:http://dx.doi.org/10.1074/jbc.M112.430785