1z58

Publication Abstract from PubMed

RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.

A crevice adjoining the ribosome tunnel: hints for cotranslational folding.,Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:15943964^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.