2oxw

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PDB ID 2oxw

Drag the structure with the mouse to rotate
, resolution 1.15Å
Ligands: and
Gene: MMP12, HME (Homo sapiens)
Activity: Macrophage elastase, with EC number 3.4.24.65
Coordinates: save as pdb, mmCIF, xml



Human MMP-12 complexed with the peptide IAG


Disease

Known diseases associated with this structure: Cardiomyopathy, dilated, 1G OMIM:[188840], Cardiomyopathy, familial hypertrophic OMIM:[188840], Muscular dystrophy, limb-girdle, type 2J OMIM:[188840], Myopathy, early-onset, with fatal cardiomyopathy OMIM:[188840], Myopathy, proximal, with early respiratory muscle involvement OMIM:[188840], Tibial muscular dystrophy, tardive OMIM:[188840]

About this Structure

2OXW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Snapshots of the reaction mechanism of matrix metalloproteinases., Bertini I, Calderone V, Fragai M, Luchinat C, Maletta M, Yeo KJ, Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5. PMID:17096442

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