3hsc
From Proteopedia
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| , resolution 1.93Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , and | ||||||
| Activity: | Adenosinetriphosphatase, with EC number 3.6.1.3 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN
Overview
The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins.
About this Structure
3HSC is a Single protein structure of sequence from Bos taurus. This structure supersedes the now removed PDB entries 2HSC and 1HSC. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein., Flaherty KM, DeLuca-Flaherty C, McKay DB, Nature. 1990 Aug 16;346(6285):623-8. PMID:2143562
Page seeded by OCA on Sun Mar 23 16:02:42 2008
