2e8p

Structural highlights

Function

[ELF3_HUMAN] Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).^{[1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11] [12] [13] [14] [15] [16] [17] [18] [19] [20] [21]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Oettgen P, Alani RM, Barcinski MA, Brown L, Akbarali Y, Boltax J, Kunsch C, Munger K, Libermann TA. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. Mol Cell Biol. 1997 Aug;17(8):4419-33. PMID:9234700
2. ↑ Andreoli JM, Jang SI, Chung E, Coticchia CM, Steinert PM, Markova NG. The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis. Nucleic Acids Res. 1997 Nov 1;25(21):4287-95. PMID:9336459
3. ↑ Chang CH, Scott GK, Kuo WL, Xiong X, Suzdaltseva Y, Park JW, Sayre P, Erny K, Collins C, Gray JW, Benz CC. ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis. Oncogene. 1997 Apr 3;14(13):1617-22. PMID:9129154 doi:http://dx.doi.org/10.1038/sj.onc.1200978
4. ↑ Tymms MJ, Ng AY, Thomas RS, Schutte BC, Zhou J, Eyre HJ, Sutherland GR, Seth A, Rosenberg M, Papas T, Debouck C, Kola I. A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer. Oncogene. 1997 Nov 13;15(20):2449-62. PMID:9395241 doi:10.1038/sj.onc.1201427
5. ↑ Choi SG, Yi Y, Kim YS, Kato M, Chang J, Chung HW, Hahm KB, Yang HK, Rhee HH, Bang YJ, Kim SJ. A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-beta type II receptor. J Biol Chem. 1998 Jan 2;273(1):110-7. PMID:9417054
6. ↑ Chang CH, Scott GK, Baldwin MA, Benz CC. Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP). Oncogene. 1999 Jun 24;18(25):3682-95. PMID:10391676 doi:http://dx.doi.org/10.1038/sj.onc.1202674
7. ↑ Chang J, Lee C, Hahm KB, Yi Y, Choi SG, Kim SJ. Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells. Oncogene. 2000 Jan 6;19(1):151-4. PMID:10644990 doi:http://dx.doi.org/10.1038/sj.onc.1203252
8. ↑ Brembeck FH, Opitz OG, Libermann TA, Rustgi AK. Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. Oncogene. 2000 Apr 6;19(15):1941-9. PMID:10773884 doi:http://dx.doi.org/10.1038/sj.onc.1203441
9. ↑ Rudders S, Gaspar J, Madore R, Voland C, Grall F, Patel A, Pellacani A, Perrella MA, Libermann TA, Oettgen P. ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene. J Biol Chem. 2001 Feb 2;276(5):3302-9. Epub 2000 Oct 17. PMID:11036073 doi:http://dx.doi.org/10.1074/jbc.M006507200
10. ↑ Park SH, Kim YS, Park BK, Hougaard S, Kim SJ. Sequence-specific enhancer binding protein is responsible for the differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric cancer cell lines: Implication for the loss of TGF-beta type II receptor expression. Oncogene. 2001 Mar 8;20(10):1235-45. PMID:11313868 doi:http://dx.doi.org/10.1038/sj.onc.1204227
11. ↑ Eckel KL, Tentler JJ, Cappetta GJ, Diamond SE, Gutierrez-Hartmann A. The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression. DNA Cell Biol. 2003 Feb;22(2):79-94. PMID:12713734 doi:http://dx.doi.org/10.1089/104454903321515896
12. ↑ Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC. ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells. J Biol Chem. 2003 Jan 10;278(2):875-84. Epub 2002 Oct 31. PMID:12414801 doi:http://dx.doi.org/10.1074/jbc.M208241200
13. ↑ Cabral A, Fischer DF, Vermeij WP, Backendorf C. Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. J Biol Chem. 2003 May 16;278(20):17792-9. Epub 2003 Mar 6. PMID:12624109 doi:http://dx.doi.org/10.1074/jbc.M300508200
14. ↑ Reddy SP, Vuong H, Adiseshaiah P. Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins. J Biol Chem. 2003 Jun 13;278(24):21378-87. Epub 2003 Apr 7. PMID:12682075 doi:http://dx.doi.org/10.1074/jbc.M212258200
15. ↑ Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravallese EM, Oettgen P. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem. 2004 Mar 26;279(13):12794-803. Epub 2004 Jan 8. PMID:14715662 doi:http://dx.doi.org/10.1074/jbc.M308593200
16. ↑ Wang H, Fang R, Cho JY, Libermann TA, Oettgen P. Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. J Biol Chem. 2004 Jun 11;279(24):25241-50. Epub 2004 Apr 8. PMID:15075319 doi:http://dx.doi.org/10.1074/jbc.M401356200
17. ↑ Prescott JD, Koto KS, Singh M, Gutierrez-Hartmann A. The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism. Mol Cell Biol. 2004 Jun;24(12):5548-64. PMID:15169914 doi:http://dx.doi.org/10.1128/MCB.24.12.5548-5564.2004
18. ↑ Schedin PJ, Eckel-Mahan KL, McDaniel SM, Prescott JD, Brodsky KS, Tentler JJ, Gutierrez-Hartmann A. ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells. Oncogene. 2004 Mar 4;23(9):1766-79. PMID:14767472 doi:http://dx.doi.org/10.1038/sj.onc.1207391
19. ↑ Grall FT, Prall WC, Wei W, Gu X, Cho JY, Choy BK, Zerbini LF, Inan MS, Goldring SR, Gravallese EM, Goldring MB, Oettgen P, Libermann TA. The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. FEBS J. 2005 Apr;272(7):1676-87. PMID:15794755 doi:http://dx.doi.org/EJB4592
20. ↑ Neve RM, Parmar H, Amend C, Chen C, Rizzino A, Benz CC. Identification of an epithelial-specific enhancer regulating ESX expression. Gene. 2006 Feb 15;367:118-25. Epub 2005 Nov 22. PMID:16307850 doi:http://dx.doi.org/10.1016/j.gene.2005.10.001
21. ↑ Kohno Y, Okamoto T, Ishibe T, Nagayama S, Shima Y, Nishijo K, Shibata KR, Fukiage K, Otsuka S, Uejima D, Araki N, Naka N, Nakashima Y, Aoyama T, Nakayama T, Nakamura T, Toguchida J. Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3. J Biol Chem. 2006 Dec 15;281(50):38941-50. Epub 2006 Oct 23. PMID:17060315 doi:http://dx.doi.org/M608389200