1uw1

From Proteopedia

Revision as of 15:04, 29 October 2007 by OCA (Talk | contribs)
(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)
Jump to: navigation, search
Image:1uw1.gif

1uw1, resolution 1.94Å

Drag the structure with the mouse to rotate

A NOVEL ADP- AND ZINC-BINDING FOLD FROM FUNCTION-DIRECTED IN VITRO EVOLUTION

Overview

A great challenge to biologists is to create proteins with novel folds and, tailored functions. As an alternative to de novo protein design, we, investigated the structure of a randomly generated protein targeted to, bind ATP. The crystal structure reveals a novel alpha/beta fold bound to, its ligand, representing both the first protein structure derived from in, vitro evolution and the first nucleotide-binding protein stabilized by a, zinc ion.

About this Structure

1UW1 is a [Single protein] structure of sequence from [[1]] with ZN and ADP as [ligands]. Full crystallographic information is available from [OCA].

Reference

A novel ADP- and zinc-binding fold from function-directed in vitro evolution., Lo Surdo P, Walsh MA, Sollazzo M, Nat Struct Mol Biol. 2004 Apr;11(4):382-3. Epub 2004 Mar 14. PMID:15024384 [[Category: ]]

Page seeded by OCA on Mon Oct 29 17:08:50 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1uw1"
Personal tools