1g62
From Proteopedia
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| , resolution 2.5Å | |||||||
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| Gene: | TIF6 (Saccharomyces cerevisiae) | ||||||
| Domains: | IF6 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF S.CEREVISIAE EIF6
Overview
Ribosome anti-association factor eIF6 (originally named according to translation initiation terminology as eukaryotic initiation factor 6) binds to the large ribosomal subunit, thereby preventing inappropriate interactions with the small subunit during initiation of protein synthesis. We have determined the X-ray structures of two IF6 homologs, Methanococcus jannaschii archaeal aIF6 and Sacchromyces cerevisiae eIF6, revealing a phylogenetically conserved 25 kDa protein consisting of five quasi identical alpha/beta subdomains arrayed about a five-fold axis of pseudosymmetry. Yeast eIF6 prevents ribosomal subunit association. Comparative protein structure modeling with other known archaeal and eukaryotic homologs demonstrated the presence of two conserved surface regions, one or both of which may bind the large ribosomal subunit.
About this Structure
1G62 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystal structures of ribosome anti-association factor IF6., Groft CM, Beckmann R, Sali A, Burley SK, Nat Struct Biol. 2000 Dec;7(12):1156-64. PMID:11101899
Page seeded by OCA on Wed Mar 26 05:52:51 2008
Categories: Saccharomyces cerevisiae | Single protein | Beckmann, R. | Burley, S K. | Groft, C M. | NYSGXRC, New York Structural GenomiX Research Consortium. | Sali, A. | Alpha-beta barrel | New york structural genomix research consortium | Nysgxrc | Protein structure initiative | Psi | Structural genomic | Subdomain | Velcro closure
