2eam

Structural highlights

Function

[ANS1B_HUMAN] Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.^{[1] [2]} Isoform 3 can regulate global protein synthesis by altering nucleolar numbers (By similarity).^{[3] [4]} Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.^{[5] [6]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Xu H, Hebert MD. A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. BMC Cell Biol. 2005 Apr 29;6(1):23. PMID:15862129 doi:http://dx.doi.org/10.1186/1471-2121-6-23
2. ↑ Ghersi E, Noviello C, D'Adamio L. Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner. J Biol Chem. 2004 Nov 19;279(47):49105-12. Epub 2004 Sep 3. PMID:15347684 doi:http://dx.doi.org/10.1074/jbc.M405329200
3. ↑ Xu H, Hebert MD. A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. BMC Cell Biol. 2005 Apr 29;6(1):23. PMID:15862129 doi:http://dx.doi.org/10.1186/1471-2121-6-23
4. ↑ Ghersi E, Noviello C, D'Adamio L. Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner. J Biol Chem. 2004 Nov 19;279(47):49105-12. Epub 2004 Sep 3. PMID:15347684 doi:http://dx.doi.org/10.1074/jbc.M405329200
5. ↑ Xu H, Hebert MD. A novel EB-1/AIDA-1 isoform, AIDA-1c, interacts with the Cajal body protein coilin. BMC Cell Biol. 2005 Apr 29;6(1):23. PMID:15862129 doi:http://dx.doi.org/10.1186/1471-2121-6-23
6. ↑ Ghersi E, Noviello C, D'Adamio L. Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner. J Biol Chem. 2004 Nov 19;279(47):49105-12. Epub 2004 Sep 3. PMID:15347684 doi:http://dx.doi.org/10.1074/jbc.M405329200