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1z77
From Proteopedia
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| , resolution 2.00Å | |||||||
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| Ligands: | , | ||||||
| Domains: | AcrR, TetR_N | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of transcriptional regulator protein from Thermotoga maritima.
Overview
The crystal structure of a putative transcriptional regulator protein TM1030 from Thermotoga maritima, a hyperthermophilic bacterium, was determined by an unusual multi-wavelength anomalous dispersion method at 2.0 A resolution, in which data from two different crystals and two different beamlines were used. The protein belongs to the tetracycline repressor TetR superfamily. The three-dimensional structure of TM1030 is similar to the structures of proteins that function as multidrug-binding transcriptional repressors, and contains a large solvent-exposed pocket similar to the drug-binding pockets present in those repressors. The asymmetric unit in the crystal structure contains a single protein chain and the twofold symmetry of the dimer is adopted by the crystal symmetry. The structure described in this paper is an apo- form of TM1030. Although it is known that the protein is significantly overexpressed during heat shock, its detailed function cannot be yet explained.
About this Structure
1Z77 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.
Reference
Crystal structure of a transcriptional regulator TM1030 from Thermotoga maritima solved by an unusual MAD experiment., Koclega KD, Chruszcz M, Zimmerman MD, Cymborowski M, Evdokimova E, Minor W, J Struct Biol. 2007 Sep;159(3):424-32. Epub 2007 May 16. PMID:17588774
Page seeded by OCA on Wed Mar 26 06:17:29 2008
Categories: Single protein | Thermotoga maritima | Chruszcz, M. | Cymborowski, M. | Koclega, K D. | Kudritska, M. | MCSG, Midwest Center for Structural Genomics. | Minor, W. | Zimmerman, M D. | Mcsg | Midwest center for structural genomic | Protein structure initiative | Psi | Structural genomic | Tetr family | Transcriptional regulator
