Structural highlights
Function
[NUP50_HUMAN] Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with multiple transport receptor proteins including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
See Also
References
- ↑ Ogawa Y, Miyamoto Y, Asally M, Oka M, Yasuda Y, Yoneda Y. Two isoforms of Npap60 (Nup50) differentially regulate nuclear protein import. Mol Biol Cell. 2010 Feb 15;21(4):630-8. doi: 10.1091/mbc.E09-05-0374. Epub 2009, Dec 16. PMID:20016008 doi:http://dx.doi.org/10.1091/mbc.E09-05-0374
