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Introduction
Regulation
Sturcture/DNA Interaction
HSF remains as a monomer when bound with Hsp under non-stressed conditions. Under stressed conditions (increased temperature) three individual monomers of HSF move into the cell’s nucleus, trimerize, and then bind to the large Groove of the DNA to Heat shock elements throughout the genome. Specifically an Arginine, and Methionine from each of the monomer bind to three oppositely oriented "AGAAN" sections of the genome.2 These residues interact with the nucleotide bases, while nearby residues inerac6t with the back bone to stabilize the transcription factor in place .
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