Cyclin-dependent kinase regulatory subunit

spinqualitylabelsall models PDB ID 1x9d Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
Human CKS 1 complex with CDK1 (PDB code 1x9d)
Ligands:	, , ,
Gene:	MAN1B1 (Homo sapiens)
Activity:	Mannosyl-oligosaccharide 1,2-alpha-mannosidase, with EC number 3.2.1.113
Related:	1fmi
Structural annotation: Resources: CATH : 1X9Da00 InterPro : Ipr001382 Pfam : PF01532 UniProt : Q9UKM7
Functional annotation: Cellular component: membrane endoplasmic reticulum integral to membrane membrane fraction Biological process: oligosaccharide metabolic process protein amino acid N-linked glycosylation metabolic process Molecular function: hydrolase activity hydrolase activity, acting on glycosyl bonds calcium ion binding mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Cyclin-dependent kinase regulatory subunit (CKS) is a small protein which is essential for the functioning of CDK-cyclin complex. CKS binds to the catalytic subunit of CDK see complex structure in the figure at top left. CKS1 is essential for CDK5 functioning in neuronal diferentiation. CKS exists as hexamer of homodimers and can bind six kinase molecules.

Function

Disease

Relevance

Structural highlights