4zd5

Structural highlights

Function

[SST2_SCHPO] Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in the multivesicular body (MVB) sorting pathway. Required for ubiquitin-dependent sorting of proteins into the endosome and subsequent trafficking to the vacuole. May regulate MVB sorting through deubiquitination of ubiquitinated ESCRT proteins.^[1]

References

1. ↑ Iwaki T, Onishi M, Ikeuchi M, Kita A, Sugiura R, Giga-Hama Y, Fukui Y, Takegawa K. Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe. Microbiology. 2007 Aug;153(Pt 8):2753-64. PMID:17660439 doi:http://dx.doi.org/10.1099/mic.0.2007/006072-0