A Disintegrin And Metalloproteinase

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A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM inhibitors are used in anti-cancer therapy. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM13 details in Molecular Playground/ADAM13. ADAM17 (TACE) processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. ADAMTS is ADAM with thrombospondin motifs. ADAMTS1 has anti-angionenic activity. ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan. ADAMTS13 cleaves von Willebrand factor involved in blood clotting.








3D Structures of A Disintegrin And Metalloproteinase

Updated on 21-October-2015

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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