2jwq
From Proteopedia
| |||||||
| Sites: | and | ||||||
| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study
Overview
The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches.
About this Structure
2JWQ is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study., Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP, ChemMedChem. 2007 May;2(5):655-66. PMID:17385760
Page seeded by OCA on Wed Mar 26 09:51:28 2008
