6-phosphogluconate dehydrogenase

From Proteopedia

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Template:STRUCTURE 1pgj

Function

6-phosphogluconate dehydrogenase (6PGD) catalyzes the decarboxylation reduction of 6-phosphogluconate (6PG) to ribulose 5-phosphate and CO2. This reaction is part of the pentose phosphate pathway. NADP is a cofactor in this reaction and is converted to NADPH.

Disease

6PGD deficiency is an autosomal hereditary disease which manifests itself by abnormal breakdown of red blood cells. Treatment involves avoidance of drugs or foods which can cause hemolysis.

3D structures of 6-phosphogluconate dehydrogenase

Updated on 25-October-2015