Adenosine A2A receptor

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Template:STRUCTURE 2ydo

Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights 5 3D Structures of adenosine A2A receptor

Function

Adenosine A2A receptor (A2AR) is one of the G protein-coupled receptors. The protein uses adenosine as the preferred endogenous agonist and is involved in increasing intracellular cAMP levels.

Disease

A2AR antagonists are being tested in the treatment of Alzheimer's Disease.

Relevance

A2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see G protein-coupled receptor.

Structural highlights

Like other G proteins, A2AR has 7 transmembrane helices. A2AR posses a ligand-binding cavity.

3D Structures of adenosine A2A receptor

Updated on 27-October-2015

3eml – hA2AR/lysozyme + antagonist – human
3qak – hA2AR/lysozyme + agonist
2ydo – hA2AR (mutant) + adenosine
2ydv – hA2AR (mutant) + agonist
3pwh, 3rey, 3rfm, 3uza, 3uzc – hA2AR (mutant) + antagonist
3vg9, 3vga – hA2AR (mutant) + antibody
4eiy – hA2AR/cytochrome b562 + antagonist