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History
With myth-like reverence, medical textbooks recount Alexander Flemming’s serendipitous observation of the antibacterial action of Penicillium mold in 1928. While not the first to note the inhibitory effect, Flemming became the first to seriously push the scientific community to research the isolation of the active compound, which he named penicillin. Eventually these efforts paid off, and in 1940, Sir Ernst Boris Chain published a method of isolating and purifying penicillin and tested its clinical effectiveness in mice. In the same year, he identified the first β-lactamase in Escherichia coli. They published their findings in a letter to the journal Nature titled, “An Enzyme from Bacteria able to Destroy Penicillin.” While interesting, this discovery was not considered clinically relevant until β-lactamase enzymes were isolated from clinical samples of gram positive bacteria by Dr. William M. M. Kirby
Function
Disease
Relevance
Structural highlights
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