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Beta-lactamase
From Proteopedia
Beta-lactamase (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets. Class C are cephalosporinases; Class A are broad-spectrum; Class B are metalloenzymes; Class D are cloxacilanases. Carbapenemase (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. Extended-spectrum Blac class A (ESBL) hydrolyze penicillins but not cephalosporins.
Relevance
Blac makes some bacteria resistant to antibiotics like penicillin, cephamycin and carbapenems.
3D Structures of Beta-lactamase
Updated on 10-November-2015
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman
