Calcineurin

From Proteopedia

Revision as of 10:34, 16 November 2015 by Michal Harel (Talk | contribs)

(diff) ←Older revision | Current revision (diff) | Newer revision→ (diff)

1 Function
2 Relevance
3 Structural highlights
4 3D structures of calcineurin
5 References

Function

Calcineurin (CN) is a eukaryotic calcium-dependent serine/threonine protein phosphatase 2B which dephosphorylates serine/threonine residues. CN activates T cells of the immune system. It participates in Ca+2-dependent signal transduction pathways. For more details see Group:MUZIC:Calcineurin.

Relevance

CN inhibitors are used as drugs in cases of rheumatic diseases, schizophrenia and diabetes. It is inhibited by immunosuppressant drugs like cyclosporine.

Structural highlights

It contains a calmodulin-binding catalytic subunit A and a Ca+2-binding regulatory subunit B. There are 2 metal ions in CN active site.

3D structures of calcineurin

Updated on 16-November-2015

1tco – CN + FK-506-binding protein + Ca + Fe + Zn – bovine
1aui - hCN + Ca + Fe + Zn – human
4il1 – CN + Ca – rat
1m63, 1mf8 - hCN + peptidyl-prolyl cis-trans isomerase + cyclosporine + Ca + Fe + Zn
2p6b - hCN + PVIVIT peptide + Ca + Fe + Zn
3ll8 - hCN + AKAP79 peptide + Ca + Fe + Zn
2jog - hCN catalytic subunit + NFAT peptide
2jzi - hCN catalytic subunit + calmodulin + Ca
2w73 - hCN calmodulin-binding domain + calmodulin + Ca
4f0z – hCN subunit B + African swine protein virus + Ca