2h0n
From Proteopedia
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| , resolution 1.53Å | |||||||
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| Sites: | and | ||||||
| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, JenaLib, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC
Overview
CeNA oligonucleotides consist of a phosphorylated backbone where the deoxyribose sugars are replaced by cyclohexene moieties. The X-ray structure determination and analysis of a fully modified octamer sequence GTGTACAC, which is the first crystal structure of a carbocyclic-based nucleic acid, is presented. This particular sequence was built with left-handed building blocks and crystallizes as a left-handed double helix. The helix can be characterized as belonging to the (mirrored) A-type family. Crystallographic data were processed up to 1.53 A, and the octamer sequence crystallizes in the space group R32. The sugar puckering is found to adopt the 3H2 half-chair conformation which mimics the C3'-endo conformation of the ribose sugar. The double helices stack on top of each other to form continuous helices, and static disorder is observed due to this end-to-end stacking.
About this Structure
2H0N is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC., Robeyns K, Herdewijn P, Van Meervelt L, J Am Chem Soc. 2008 Feb 13;130(6):1979-84. Epub 2008 Jan 17. PMID:18198873
Page seeded by OCA on Wed Mar 26 10:01:31 2008
