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CD44

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Revision as of 12:42, 24 November 2015 by Alexander Berchansky (Talk | contribs)

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Structure of mouse CD44 hyaluronan-binding domain complex with 8-mer HA (PDB entry 2jcq)

Drag the structure with the mouse to rotate

Function

CD44 is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow.

Relevance

CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases.

3D structures of CD44

Updated on 24-November-2015

1uuh, 4pz4 – hCD44 hyaluronan-binding domain – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
2jcp - mCD44 hyaluronan-binding domain – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, 4np3 - mCD44 hyaluronan-binding domain + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide