Function
A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM family members are numbered.
- ADAM10 cleaves ephrin.
- ADAM13 details are in Molecular Playground/ADAM13.
- ADAM17 (TACE) processes the tumor necrosis factor-α.
- ADAM33 is implicated in asthma.
- ADAMTS is ADAM with thrombospondin motifs.
- ADAMTS1 has anti-angionenic activity.
- ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan.
- ADAMTS13 cleaves von Willebrand factor involved in blood clotting.
Disease
ADAM inhibitors are used in anti-cancer therapy. ADAM33 is implicated in asthma. ADAMTS13 cleaves von Willebrand factor involved in blood clotting.
