Function
Acid phosphatase (ACP, EC number 3.1.3.2) is an enzyme which removes phosphate from other molecules during digestion. It catalyzes the conversion of orthophosphoric monoester and H2O to alcohol and phosphoric acid. The enzyme is most effective in acidic environment, hence its name.[1]
- Prostatic ACP (PSAP) is produced by the prostate.
- Purple ACP (PAP) or tartrate-resistant ACP contains a dinuclear Fe center and their oxidized form in solution maintains a purple color.
- Histidine ACP (HAP) catalyzes the transfer of phosphoryl group using an active-site histidine.
Disease
PSAP is found in increased amounts in patients who have prostate cancer.
Relevance
PSAP was used as a prostate cancer marker before the develpement of prostate specific antigen (PSA) as one.
