Cholesterol esterase

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Contents 1 Function 2 Disease 3 Structural highlights 4 3D structures of cholesterol esterase 5 References

Function

Cholesterol esterase (ChoE) also named bile-acid activated lipase catalyzes the hydrolytic cleavage of cholesterol, other sterol esters and triglycerides.

Disease

Deficiency of this enzyme causes Wolman’s disease and cholesteryl ester storage disease.

Structural highlights

ChoE ligand-binding tunnel is ca. 30 A long and has the catalytic triad Ser-His-Glu at the opening and hydrophobic residues lining the bottom cup.^[1] </StructureSection>

3D structures of cholesterol esterase

Updated on 07-December-2015

References

1. ↑ Pletnev V, Addlagatta A, Wawrzak Z, Duax W. Three-dimensional structure of homodimeric cholesterol esterase-ligand complex at 1.4 A resolution. Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):50-6. Epub 2002 Dec, 19. PMID:12499539