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Sandbox T1SS T2SS

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4RIU

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Contents

Function

A protein is first transported from the cytoplasm to the periplasm via the Sec or Tat pathway, before being transported to the extracellular environment [1]. Proteins secreted via T2SS include proteases, cellulases, pectinases, phospholipases, lipases, and toxins, many of which are virulence factors [2]. For instance, pathogens such as Vibrio cholerae and Pseudomonas aeruginosa employ the T2SS pathway [3].

Structure

Energetics

References

  1. ↑ Cianciotto, Nicholas. “Type II secretion: a protein secretion system for all seasons.” 2005. Trends in Microbiology 13: 581-588.
  2. ↑ Sandkvist, Maria. “Type II Secretion and Pathogenesis.” 2001. Infection and Immunity 69: 3523-3535.
  3. ↑ Lu, Connie, Stewart Turley, Samuel T. Marionni, et al. “Hexamers of the Type II Secretion ATPase GspE from Vibrio cholerae with Increased ATPase Activity.” 2013. Cell 21: 1707-1717.

Authors

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