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Crystallin
From Proteopedia
Contents |
Function
Crystalline is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. α-, β-, γ-, δ-crystalline are named according to the order they are eluted by gel filtration. δ-crystalline is found in avian and reptilian lenses.[1]
Disease
Several human cataracts have been linked to mutations in γ-D-crystalline.
3D Structures of Crystalline
Updated on 15-December-2015
2g98 - hγ-D-crystalline – human
1h4a - hγ-D-crystalline (mutant)
1elp - γ-D-crystalline – bovine
1auw - δ-2-crystalline (mutant) - duck
References
- ↑ Basak A, Bateman O, Slingsby C, Pande A, Asherie N, Ogun O, Benedek GB, Pande J. High-resolution X-ray crystal structures of human gammaD crystallin (1.25 A) and the R58H mutant (1.15 A) associated with aculeiform cataract. J Mol Biol. 2003 May 16;328(5):1137-47. PMID:12729747
