1au6
From Proteopedia
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| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF DNA D(CATGCATG) INTERSTRAND-CROSSLINKED BY BISPLATIN COMPOUND (1,1/T,T), NMR, MINIMIZED AVERAGE STRUCTURE
Overview
The bifunctional platinum compound, [(trans-PtCI(NH)3)2)2(H2N(CH2)4NH2)]2+, forms a stable adduct with the self-complementary DNA oligomer CATGCATG, with the two platinum atoms coordinated at the N7 positions of the two symmetrical G4 nucleotides. The NMR-derived structure shows that the DNA octamer forms a novel hairpin structure with the platinated G4 residue adopting a syn conformation and the guanine base in the minor groove. Two such hairpins stack end-over-end and are linked together by the butanediamine tether to form a dumbbell structure. Such unusual structural distortion is different from that of the anticancer drug cisplatin-DNA adduct and may provide clues to explain the distinct biological activities of the two compounds.
About this Structure
1AU6 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA., Yang D, van Boom SS, Reedijk J, van Boom JH, Farrell N, Wang AH, Nat Struct Biol. 1995 Jul;2(7):577-8. PMID:7664126
Page seeded by OCA on Sun Mar 30 18:47:37 2008
