Function
D-alanine-D-alanine ligase (DDL) catalyzes the conversion of 2 alanine molecules and ATP to D-alanine-D-alanine and ADP. DDL is part of the bacterial peptidoglycan synthesis pathway and the alanine metabolism.[1]
Relevance
DDL acts in bacterial cell wall synthesis and its inhibition is a target of novel antibiotics search.
Structural highlights
DDL structure contains 3 α/β domains. The ADP-binding site is found between domains 1 and 2.