Dual specificity phosphatase

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Dual specificity phosphatase (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:
• Slingshot phosphatase[1]
• Phosphatase of regenerating liver[2]
• Cdc14[3]
• Cdc25[4]
• PTEN[5]
• Myotubularin[6]
• MAPK phosphatase see MAP kinase phosphatase

3D structures of dual specificity phosphatase

Updated on 03-January-2016

References

  1. ↑ Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC. The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. J Biol Chem. 2007 Nov 2;282(44):32520-8. Epub 2007 Sep 11. PMID:17848544 doi:http://dx.doi.org/10.1074/jbc.M707041200
  2. ↑ Walls CD, Iliuk A, Bai Y, Wang M, Tao WA, Zhang ZY. Phosphatase of regenerating liver 3 (PRL3) provokes a tyrosine phosphoproteome to drive prometastatic signal transduction. Mol Cell Proteomics. 2013 Dec;12(12):3759-77. doi: 10.1074/mcp.M113.028886. Epub , 2013 Sep 12. PMID:24030100 doi:http://dx.doi.org/10.1074/mcp.M113.028886
  3. ↑ Stegmeier F, Amon A. Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. Annu Rev Genet. 2004;38:203-32. PMID:15568976 doi:http://dx.doi.org/10.1146/annurev.genet.38.072902.093051
  4. ↑ Kristjansdottir K, Rudolph J. Cdc25 phosphatases and cancer. Chem Biol. 2004 Aug;11(8):1043-51. PMID:15324805 doi:http://dx.doi.org/10.1016/j.chembiol.2004.07.007
  5. ↑ Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. 1999 Oct 29;99(3):323-34. PMID:10555148
  6. ↑ Nandurkar HH, Layton M, Laporte J, Selan C, Corcoran L, Caldwell KK, Mochizuki Y, Majerus PW, Mitchell CA. Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP. Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):8660-5. Epub 2003 Jul 7. PMID:12847286 doi:http://dx.doi.org/10.1073/pnas.1033097100

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