D-xylose isomerase

Function

D-xylose isomerase (DXI) catalyzes the conversion of D-xylose (DX) to D-xylitol. DXI is part of the fructose and mannose metabolism pathways. Sorbitol is a competitive inhibitor of DXI. DXI is a metal-ion activated tetramer.^[1]

Relevance

DXI is used commercially in the production of high fructose corn syrup.

3D structures of D-xylose isomerase

Updated on 11-January-2016

References

1. ↑ MARSHALL RO, KOOI ER. Enzymatic conversion of D-glucose to D-fructose. Science. 1957 Apr 5;125(3249):648-9. PMID:13421660