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Eukaryotic initiation factor

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Revision as of 16:54, 20 January 2016 by Michal Harel (Talk | contribs)
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Contents

Function

Eukaryotic initiation factors (EIF) are involved in the initiation of protein translation. They form a complex with the small subunit of the ribosome and Met-tRNA which scans the mRNA and recognizes the initiation codon AUG[1]. For details on EIF4 see C-terminal portion of human eIF4GI.

Disease

Overexpression of individual subunits of eIF3 may cause malignant transformation [2].

Structural insights

EIF domains include the N terminal domain (NTD), C terminal domain (CTD), RNA recognition domain, middle domain, PAZ domain of EIF2C and a protein-protein interaction domain (PCI) of EIF3. </StructureSection>

3D structures of eukaryotic initiation factor

Updated on 20-January-2016

References

  1. ↑ Jivotovskaya AV, Valasek L, Hinnebusch AG, Nielsen KH. Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol. 2006 Feb;26(4):1355-72. PMID:16449648 doi:http://dx.doi.org/10.1128/MCB.26.4.1355-1372.2006
  2. ↑ Hershey JW. The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 2015 Jul;1849(7):792-800. doi:, 10.1016/j.bbagrm.2014.10.005. Epub 2014 Nov 1. PMID:25450521 doi:http://dx.doi.org/10.1016/j.bbagrm.2014.10.005

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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