Fibronectin

Function

Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion^[1].

Relevance

Fn is associated with wound healing. Fn is a potential marker for radiation resistance.

Disease

Overexpression of Fn1 is associated with lung cancer.

Structural insights

Fn is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI₆-FnII_1-2-FnI_7-9 is the gelatin binding domain (GBD).