Monocyte chemoattractant protein

Function

Human synthetic monocyte chemoattractant protein 1 (3IFD) belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The gene for MCP1 is on chromosome 17 in region 17q11.2-q12. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines. The MCP-1^[1] is also known as chemokine (C-C motif) ligand or CCL2 or: - small inducible cytokine A2 (SCYA2) - MCAF - GDCF-2 - SMC-CF - HSMCR30 - MGC9434 - GDCF-2 - HC11.

It exists as a monomer or a dimer, eventhough the homodimer form is preferred.

-> Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans.

Ligands

K and PO4

Disease

CCL2 is implicated in several diseases like psoriasis, rheumatoid arthritis and atherosclerosis.

MPC1 is implicated in rheumatoid arthritis where they may serve to recruit macrophages and perpetuate the inflammation in the joints. MPC1 has also been found elevated in the urine of people with lupus as a sign warning of inflammation of the kidney.

Relevance

CCL2 is overexpressed in epilepsy, brain ischemia, Alzheimer's disease, EAE and traumatic brain injury.

Structural highlights

CCL2 is part of the C-C motif group because of the covalent bond made between .^[2] Post translational modifications at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant.