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MMP8

MMP-8, also called, Neutrophil collagenase or Collagenase 2, is a zinc-dependent and calcium-dependent enzyme. It belongs to the matrix metalloproteinase (MMP) family which is involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The gene coding this family is localized on the chromosome 11 of Homo sapiens .[1]


PDB ID 2oy4

Drag the structure with the mouse to rotate

References

  1. "MMP8 matrix metallopeptidase 8 (neutrophil collagenase)"
  2. Stams T, Spurlino JC, Smith DL, Wahl RC, Ho TF, Qoronfleh MW, Banks TM, Rubin B. Structure of human neutrophil collagenase reveals large S1' specificity pocket. Nat Struct Biol. 1994 Feb;1(2):119-23. PMID:7656015
  3. "Neutrophil collagenase"
  4. "Metalloendopeptidase activity"



RESSOURCE : Image:2oy4 mm1.pdb ( la structure du monomère )

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