1nzn

Structural highlights

Function

[FIS1_HUMAN] Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.^{[1] [2] [3] [4] [5]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ James DI, Parone PA, Mattenberger Y, Martinou JC. hFis1, a novel component of the mammalian mitochondrial fission machinery. J Biol Chem. 2003 Sep 19;278(38):36373-9. Epub 2003 Jun 3. PMID:12783892 doi:http://dx.doi.org/10.1074/jbc.M303758200
2. ↑ Yoon Y, Krueger EW, Oswald BJ, McNiven MA. The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol. 2003 Aug;23(15):5409-20. PMID:12861026
3. ↑ Stojanovski D, Koutsopoulos OS, Okamoto K, Ryan MT. Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology. J Cell Sci. 2004 Mar 1;117(Pt 7):1201-10. PMID:14996942 doi:http://dx.doi.org/10.1242/jcs.01058
4. ↑ Yu T, Fox RJ, Burwell LS, Yoon Y. Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1. J Cell Sci. 2005 Sep 15;118(Pt 18):4141-51. Epub 2005 Aug 23. PMID:16118244 doi:http://dx.doi.org/jcs.02537
5. ↑ Koch A, Yoon Y, Bonekamp NA, McNiven MA, Schrader M. A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell. 2005 Nov;16(11):5077-86. Epub 2005 Aug 17. PMID:16107562 doi:http://dx.doi.org/E05-02-0159