Structural highlights
2vi8 is a 1 chain structure with sequence from Atcc 12980. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Related: | 2vgu, 1yjy, 1yjs, 1kl2, 1kl1, 1kkp, 2vgs, 1yjz, 2vgt, 2vgv, 1kkj, 2vgw, 2vib, 2via, 2vi9 |
| Activity: | Glycine hydroxymethyltransferase, with EC number 2.1.2.1 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum |
Function
[Q7SIB6_GEOSE] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.[HAMAP-Rule:MF_00051]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
See Also
